Clinical study on bone resorption biochemical marker of second generation serum tartrate-resistant acid phosphatase (TRACP) 5b
Calcif Tissue Int 72, Abstract P51
Xiang Q1, Su N1, Liu ZH1, Yin DQ2, Zhu HM3, Chen SY3, Tan ZL4, Wang L4, Lu JH5, Qin YJ5
1China-Japan Friendship Hospital, 100029, Beijing, P.R.China
2Beijing JiShuiTan Hospital, P.R.China
3Shanghai North China Hospital, P.R.China
4Tianjin Hospital, P.R.China
5The Sixth Hospital of Shanghai, P.R.China
Abstract
Osteoporosis is the major cause of morbidity and mortality in the elderly population. Early diagnosis of osteoporosis are concerned by scientists. A problem with the first generation markers of bone resorption is that their normal levels vary a lot between individuals. Although these markers are useful in selecting and mornitoring antiresorptive treatment and in the prediction of osteoporotic fractures, it is difficult to be a biomarker of osteoporotic diagnosis. The novel study showed that tartrate-resistant acid phosphatase (TRACP) 5b maybe a good second generation biomarker of osteoporosis.
The serum of 437 person were detected with Bone TRAP kits in several hospitals of China. Our data implied that serum TRACP 5b level of osteoporosis patients and older person (man>or=65, woman>or=50) are higher than normal. It will be a convenient, reliable and economical new method for determination for bone resorption rate from serum samples.
Our data showed that the serum TRACP 5b level were lower in men before 64 and in women before 49 years old respectively. But their TRACP5b level and bone resorption, especially in osteoporotic patients, were increased climacterum later, and there are markedly differentiation compared with adult and control groups in statistics. These results implied that the serum TRACP 5b may be a more specific marker in mornitoring bone resorption and osteoporosis diagnosis.
| Age | No. | TRACP 5b value X ±SD | t-test | ||
|---|---|---|---|---|---|
| Normal male | 20-64 | 87 | 3.76 ±1.35 | ||
| Normal male | >=65 | 79 | 4.66±1.50 | *p<0.01 | |
| osteoporotic male | >=60 | 58 | 5.69±1.86 | *p<0.01 | **p<0.01 |
| Normal female | 20-49 | 73 | 2.89±1.28 | ||
| Normal female | >=50 | 115 | 4.81±1.54 | #p<0.01 | |
| osteoporotic female | >=45 | 61 | 5.24 ±1.65 | #p<0.01 | ##p<0.05 |
| *— compared with 20-64 group **— compared with >=65 group #— compared with 20-49 group ##— compared with >=50 group | |||||