Serum tartrate-resistant acid phosphatase 5b and osteocalcin in naturally occurring osteopetrotic rats
J Bone Miner Res 18 (Suppl. 1), Abstract SA095
Alatalo SL1, Ivaska KK1, Peng Z1, Halleen JM1, Marks SC Jr2, Väänänen HK1
1Institute of Biomedicine, Department of Anatomy, University of Turku, Turku, Finland
2Department of Cell Biology, University of Massachusetts Medical Center, Worcester, MA, USA
Introduction
Osteopetrosis is a rare, genetic disorder due to markedly decreased bone resorption as a result of several different osteoclastic abnormalities. Three different naturally occurring osteopetrotic rat strains have been identified; toothless ( tl/tl) containing severely reduced number of osteoclasts with normal ruffled borders, osteopetrotic ( op/op) containing slightly reduced number of osteoclasts with poorly developed ruffled borders, and incisors absent ( ia/ia) containing markedly increased number of osteoclasts without ruffled borders. The defected gene in tl/tl mutation is colonystimulating factor (CSF-1 or M-CSF)1, but the mutations in op/op and ia/ia rats are still unknown.