Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation
J Pediatr Hematol Oncol. 2004 Jan;26(1):5-8
Chen CJ, Chao TY, Chu DM, Janckila AJ, Cheng SN
Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Abstract
The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation
PMID: 14707702 [PubMed - indexed for MEDLINE]