This bibliography of peer-reviewed scientific papers and presented abstracts and posters is provided for educational purposes only. It is an aid to researchers who are interested in previously published clinical research studies using serum tartrate-resistant acid phosphatase 5b (TRACP 5b).
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| Title | Authors | Publication / Event |
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| » Biochemical markers of bone metabolism and prediction of fracture in elderly women | Gerdhem P, Ivaska KK, Alatalo SL, Halleen JM, Hellman J, Isaksson A, Pettersson K, Väänänen HK, Åkesson K, Obrant KJ 2004 | J Bone Miner Res; 19:386-393 |
| » Tartrate-resistant acid phosphatase 5B is a specific and sensitive marker of bone resorption (Review) | Halleen JM 2003 | Anticancer Res 23(2A):1027-1029 |
| » Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption | Halleen JM, Alatalo SL, Janckila AJ, Woitge HW, Seibel MJ, Väänänen HK 2001 | Clin Chem 47:597-600 |
| » Tartrate-resistant acid phosphatase 5b, a novel serum marker of bone resorption | Halleen JM, Alatalo SL, Suominen H, Cheng S, Janckila AJ, Väänänen HK 2000 | J Bone Miner Res 15:1337-1345 |
| » Comparison of serum tartrate-resistant acid phosphatase 5b with other markers of bone turnover in monitoring alendronate therapy | Halleen JM, Nenonen AM, Alatalo SL, Ivaska KK, Cheng S, Schmidt-Gayk H, Uusi-Rasi K, Heinonen A, Kannus P, Sievänen H, Väänänen HK 2003 | J Bone Miner Res 18 (Suppl.1), Abstract SA104 |
| » Clinical performance of immunoreactive tartrate resistant acid phosphatase isoform 5b as a marker of bone resorption | Hannon RA, Clowes JA, Eagleton AC, Al Hadari AA, Eastell R, Blumsohn A 2004 | Bone 34:187-194 |
| » Comparison of serum bone resorption markers in the diagnosis of skeletal metastasis | Koizumi M, Takahashi S, Ogata E 2003 | Anticancer Res 23:4095-4099 |
| » Tartrate-resistant acid phosphatase as serum marker of bone metabolism in cancer patients | Mose S, Menzel C, Kurth AA, Obert K, Breidert I, Borowsky K, Böttcher H-D 2003 | Anticancer Res 23:2783-2788 |
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| Title | Authors | Publication / Event |
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| » Serum tartrate-resistant acid phosphatase 5b as a marker of bone metastases in prostate cancer | Alatalo SL, Ala-Houhala M, Korpela J, Halleen JM, Väänänen HK, Koskinen A, Helenius H, Salminen E 2003 | J Bone Miner Res 18 (Suppl. 1), Abstract SA094 |
| » Evaluation of tartrate-resistant acid phosphatase (TRAP) 5b as serum marker of bone metastases in human breast cance | Capeller B, Caffier H, Sutterlin MW, Dietl J 2003 | Anticancer Res 23:1011-1015 |
| » Tartrate-resistant acid phosphatase 5b as a serum marker of bone metastasis in breast cancer patients | Chao TY, Ho CL, Lee SH, Chen MM, Janckila A, Yam LT 2004 | J Biomed Sci 11(4):511-516 |
| » Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications | Jung K, Lein M, Stephan C, Von Hosslin K, Semjonow A, Sinha P, Loening SA, Schnorr D 2004 | Int J Cancer 111(5):783-791 |
| » Bone metabolic markers in bisphosphonate therapy for skeletal metastases in patients with breast cancer | Koizumi M, Takahashi S, Ogata E 2003 | Breast Cancer 10:21-27 |
| » Serum tartrate-resistant acid phosphatase 5b as a marker of bone metastases in prostate cancer | Maddison R, Kyd PA, Swinn M, Fairney A 2003 | Calcif Tissue Int 72, Abstract P10 |
| » Serum levels of tartrate-resistant acid phosphatase-5b in breast cancer patients treated with pamidronat | Martinetti A, Seregni E, Ripamonti C, Ferrari L, De Conno F, Miceli R, Pallotti F, Coliva A, Biancolini D, Bombardieri E 2002 | Int J Biol Markers 17:253-258 |
| » Evaluation of tartrate-resistant acid phosphatase (trap) as serum marker of bone resorption in irradiated bone metastases | Politou M, Terpos E, Anagnostopoulos A, Szydlo R, Laffan M, Layton M, Apperley JF, Dimopoulos MA, Rahemtulla A 2004 | XXI Annual Meeting of the European Society of Radiotherapy and Oncology, Abstract 551 |
| » Role of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS) | Terpos E, Politou M, Szydlo R, Nadal E, Avery S, Olavarria E, Kanfer E, Goldman JM, Apperley JF, Rahemtulla A 2004 | Br J Haematol 126(5):686-689 |
| » Tartrate-resistrant acid phosphatase isoform 5b; a novel serum marker for monitoring bone disease in multiple myeloma | Terpos T, de la Fuente J, Szydlo R, Hatjiharissi E,Viniou N, Meletis J, Yataganas X, Goldman JM, Rahemtulla A 2003 | Int J Cancer 106:455-457 |
| » Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma | Terpos E, Politou M, Szydlo R, Nadal E, Avery S, Olavarria E, Kanfer E, Goldman JM, Apperley JF, Rahemtulla A 2004 | Leukemia 18(8):1420-1426 |
| » Unusual association between increased bone resorption and presence of paroxysmal nocturnal hemoglobinuria phenotype in multiple myeloma | Terpos E, Samarkos M, Meletis C, Apostolidou E, Tsironi M, Korovesis K, Mavrogianni D, Viniou N, Meletis J 2003 | Int J Hematol 7:344-348 |
| » Pamidronate is superior to ibandronate in decreasing bone resorption, interleukin-6 and beta 2-microglobulin in multiple myeloma | Terpos T, Viniou N, de la Fuente J, Meletis J, Voskaridou E, Karkantaris C, Vaiopoulos G, Palermos J, Yataganas X, Goldman J, Rahemtulla A 2003 | Eur J Haematol 70:34-42 |
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| Title | Authors | Publication / Event |
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| » Does hysterectomy with ovarian conservation affect bone metabolism and density | Cheng S, Sievanen H, Heininen A, Uusi-Rasi K, Carbone L, Tyylavsky F, Hallen J, Kannus P 2003 | J Bone Miner Metabol 21:12-16 |
| » Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls | Cheng S, Tylavsky F, Kröger H, Karkkainen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen HK, Lamberg-Allardt C 2003 | Am J Clin Nutr 78(3):485-492 |
| » Measurement of OPG, RANKL, and TRAP 5b in the serum of elderly patients with active Paget's disease | Durham BH, Daroszewkska A, Fraser WD 2003 | Calcif Tissue Int 72, Abstract P11 |
| » Correlation between serum markers of osteoblast/osteoclast interactivity, collagen formation and resorption in elderly Pagetic patients | Durham BH, Dutton JJ, Fraser WD 2003 | J Bone Miner Res 18 (Suppl.1), Abstract M401 |
| » Serum tartrate-resistant acid phosphatase 5b is an independent predictor of bone mineral density in women but not in men. (abstract) | Franzson L, Indridason OS, Sigurdsson G. | |
| » Serum tartrate-resistant acid phosphatase 5b, but not 5a, correlates with other markers of bone turnover and bone mineral density | Halleen JM, Ylipahkala H, Alatalo SL, Janckila AJ, Heikkinen JE, Suominen H, Cheng S, Väänänen HK 2002 | Calcif Tissue Int 71:20-25 |
| » The effect of raloxifene on markers of bone turnover in older women living in long-term care facilities | Hansdottir H, Franzson L, Prestwood K, Sigurdsson G 2004 | J Am Geriatr Soc 52(5):779-783 |
| » Serum osteoprotegerin and its relationship with bone mineral density and markers of bone turnover | Indridason OS, Franzson L, Sigurdsson G 2004 | Osteoporos Int. 2004 Jul 20 |
| » Immunological and histochemical determination of TRAP 5b to measure osteoclast activity under antiosteolytic treatment | Mehlhorn AT, Rechl H, Stemberger AW, Gradinger r 2002 | Calcif Tissue Int 70, Abstract P21 |
| » The association of bone metabolism with bone mineral density, serum sex hormone concentrations, and regular exercise in middle-aged men | Remes T, Vaisanen SB, Mahonen A, Huuskonen J, Kroger H, Jurvelin JS, Penttila IM, Rauramaa R | Bone 35(2):439-447 |
| » Development and characterization of a novel human in vitro bone resorption assay useful for preclinical testing of drug candidates | Rissanen JP, Hentunen TA, Halleen JM 2003 | J Bone Miner Res 18 (suppl.1), Abstract SA256 |
| » Serum activity of type 5b ACP and biochemical markers of type I collagen degradation in osteoporotic men with Klinefelter's syndrome treated with an intravenous ibandronate | Stepan JJ, Burckhardt p 2002 | Calcif Tissue Int 70, Abstract P79 |
| » Effects of a 12 months risedronate treatment on biochemical markers of bone turnover and on serum osteoprotegerin and soluble receptor activator of NF-kB ligand in postmenopausal osteoporotic women | Truniger R, Popp AWE, Perrelet R, Noesberger A, Lippuner K 2003 | J Bone Miner Res 18 (suppl. 1), Abstract SU341 |
| » Pamidronate is an effective treatment for osteoporosis in patients with beta-thalassaemia | Voskaridou E, Terpos E. Spina G, Palmeros J, Rahemtulla A, Loutradi A, Loukopoulos D 2003 | Br J Haematol 1234:730-737 |
| » Clinical study on bone resorption biochemical marker of second generation serum tartrate-resistant acid phosphatase (TRACP) 5b | Xiang Q, Su N, Liu ZH, Yin DQ, Zhu HM, Chen SY, Tan ZL, Wang L, Lu JH, Qin YJ 2003 | Calcif Tissue Int 72, Abstract P51 |
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| Title | Authors | Publication / Event |
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| » Low dialysate-Ca++ stimulates PTH & substitution with 25(OH) vitamin D3 results in hyperphosphatemia in hemodialysis patients | Albertini B, Casez JP, Koller D, Cheneval JP, Wauters JP, Jaeger PH 2002 | J Am Soc Nephrol 13 |
| » Low levels of 25-hydroxy-vitamin D3 (25OHD) and high serum tartrate resistant acid phosphatase 5b (TRAP 5b) activity in hemodialysis patients: relationship to secondary hyperparathyroidis | Albertini B, Casez JP, Cheneval JP, Wauters JP, Jaeger ph 2002 | J Am Soc Nephrol 12 |
| » Correlation between histomorphometric parameters of bone resorption and serum type 5b tartrate-resistant acid phosphatase in uremic patients on maintenance hemodialysis | Chu P, Chao TY, Lin YF, Janckila AJ, Yam LT 2003 | Am J Kidney Dis 41:1052-1059 |
| » Correlations of new markers of bone formation and resorption in kidney transplant recipients | Malyszko J, Wolczynski S, Malyszko JS, Konstantynowicz J, Kaczmarski M, Mysliwiec M 2003 | Transplant Proc 35:1351-1354 |
| » The N-terminal propeptide of type I procollagen-(PINP) and tartrate resistant acid phosphatase-(TRAP-5b) as bone turnover markers in dialysed patients | Nowak Z, Konieczna M, Wankowicz Z 2003 | Calcif Tisse Int 72, Abstract P19 |
| » Influence of PTH Assay Methodology on Differential Diagnosis of Renal Bone Disease | Reichel H, Esser A, Roth HJ, Schmidt-Gayk H 2003 | Nephrol Dial Transplant 18:759-768 |
| » Electrophoretic study of tartrate-resistant acid phosphatase isoforms in endstage renal disease and rheumatoid arthritis | Takahashi K, Janckila AJ, Sun SZ, Lederer ED, Ray PC, Yam LT 2000 | Clin Chim Acta 301:147-158 |
| » Tartrate-resistant acid phosphatase (TRAP) in children with chronic renal failure (CRF) | Tsolkas H, Timmermann K, Holst G, Altrogge H, Müller-Wiefel DE 2001 | Pediatric Nephrology 16, Abstract P458 |
| » Tartrate-resistant acid phosphatase isoform 5b (TRAP): a novel serum marker of bone resorption in haemodialysis patients | Wahl HG, Bandorski M, Bandorski D, Graf ST, Sahlfeld D, Bohner J, Fassbinder W | XIX Congress of the European Renal Association, Copenhagen |
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| Title | Authors | Publication / Event |
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| » Serum tartrate-resistant acid phosphatase 5b and osteocalcin in human type II autosomal dominant osteopetrosis | Alatalo SL, Ivaska KK, Waguespack SG, Econs MJ, Väänänen HK, Halleen JM 2003 | Calcif Tissue Int 72, Abstract P27 |
| » Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation | Chen CJ, Chao TY, Chu DM, Janckila AJ, Cheng SN 2004 | J Pediatr Hematol Oncol 26:5-8 |
| » Tartrate-resistant acid phosphatase as a serum marker of bone resorption (Review) | Halleen JM, Ranta R 2001 | Am Clin Lab 20:29-30 |
| » Disease-specific expression of tartrate-resistant acid phosphatase isoforms | Janckila AJ, Nakasato YR, Neustadt DH, Yam LT 2003 | J Bone Miner Res 18:1916-1919 |
| » Serum tartrate-resistant acid phosphatase isoforms in rheumatoid arthritis | Janckila AJ, Neustadt DH, Nakasato YR, Halleen JM, Hentunen T, Yam lt 2002 | Clin Chim Acta 320:49-58 |
| » Stable expression of human tartrate-resistant acid phosphatase isoforms by CHO cells | Janckila AJ, Parthasarathy RN, Parthasarthy LK, Seelan RS, Yam LT 2002 | Clin Chim Acta 326:113-122 |
| » Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity | Janckila AJ, Takahashi K, Sun SZ, Yam LT 2001 | Clin Chem 47:74-80 |
| » Intracellular machinery for matrix degradation in bone-resorbing osteoclasts | Vääräniemi J, Halleen JM, Kaarlonen K, Ylipahkala H, Alatalo SL, Andersson G, Kaija H, Vihko P, Väänänen HK 2004 | J Bone Miner Res 19(9):1432-1440 |
| » Tartrate-resistant acid phosphatase 5b circulates in human serum in complex with alpha2-macroglobulin and calcium | Ylipahkala H, Halleen JM, Kaija H, Vihko P, Väänänen HK 2003 | Biochem Biophys Res Commun 308(2):320-324 |
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| Title | Authors | Publication / Event |
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| » Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium | Alatalo SL, Halleen JM, Hentunen TA, Mönkkönen J, Väänänen HK 2000 | Clin Chem 46:1751-1754 |
| » Estrogen receptor specificity in the regulation of skeletal growth and trabecular BMD in female mice | Lindberg MK, Alatalo SL, Halleen JM, Gustafsson J-Å, Ohlsson C 2001 | J Endocrinol 171:229-236 |
| » ER(alfa) but not ER(beta) is involved in the regulation of the OPG/RANKL ratio and serum IL-6 in male mice | Lindberg MK, Erlandsson M. Alatalo SL, Windahl S, Andersson G, Halleen JM, Carlsten H, Gustaffsson J-Å, Ohlsson C 2001 | J Endocrinol 171:425-433 |
| » Two different pathways for the maintenance of trabecular bone in adult male mice | Lindberg MK, Moverare S, Skrtic S, Alatalo SL, Halleen JM, Mohan S, Gustaffsson J-Å, Ohlsson C 2002 | J Bone Miner Res 17:555-562 |
Immunoassays for Bone Metabolism